Concordance and Discordance of Mitotic Count, Ki-67 Proliferative Index and Phosphohistone H3 Count in Grading Neuroendocrine Tumors of Gastrointenstinal Tract

Objective: To determine the grades of gastrointestinal neuroendocrine tumours using World Health Organization criteria and Phosphohistone H3 mitotic index to concordance between two methods.
 Study Design: Cross-sectional study.
 Place Duration Study: Department Histopathology, Armed Forces Institute Pathology, Rawalpindi Pakistan, from Mar Oct 2019.
 Methodology: Forty-two (n=42) patients either gender ages 18-70 years were enrolled. All enrolled diagnosed with primary underwent surgical or endoscopic resection. Tumour determined H3mitotic index. The results obtained both methods compared, rate was calculated.
 Results: When counts through PHH3, MI resulted in a change grade 12 (28.6%) tumours, which graded by current WHO system. 11 (26.2%) changed II I 1 (2.4%) I1. agreement (concordance rate) systems moderate statistically significant (71.4%, n=30/42, κ= 0.51, p= 0.001).
 Conclusion: In present study, we observed Ki-67 labelling PPH3 index, correlate well counts. demonstrated better correlation when compared LI. Hence, inference can be drawn that H3is associated more closely mitosis tumours.